Go to the following directory on the machine hosting IIS. Navigate to the following directory.

C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727 (or other .NET folder)

Execute the following command:

aspnet_regiis -i

Now your .NET applications should execute through IIS, provided you have IIS configured correctly.

To all of my readers, I want to wish you each a Merry Christmas and Happy Holidays! May you have safe travels and good tidings.